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2 edition of Regulation of neural cell adhesion molecule polysialylation state found in the catalog.

Regulation of neural cell adhesion molecule polysialylation state

Helen Christine Gallagher

Regulation of neural cell adhesion molecule polysialylation state

by Helen Christine Gallagher

  • 165 Want to read
  • 4 Currently reading

Published by University College Dublin in Dublin .
Written in English

    Subjects:
  • Cell adhesion molecules.,
  • Neuropharmacology.

  • Edition Notes

    Statementby Helen Christine Gallagher.
    ContributionsUniversity College Dublin. Department of Pharmacology.
    The Physical Object
    Paginationxi,240p. :
    Number of Pages240
    ID Numbers
    Open LibraryOL18823053M

    1 Introduction. Sialic acid [] is the most abundant terminal monosaccharide on glycoconjugates of the eukaryotic cell surface. It is involved in a variety of cellular functions, such as cell–cell interaction, virus infection or the stability of glycoproteins [].One prominent example of a highly sialylated glycoprotein is the neural cell adhesion molecule NCAM []. Polysialylation is a rare posttranslational modification executed by the two enzymes ST8Sia II and ST8Sia IV ().These polysialyltransferases generate long α2,8-linked linear homopolymers of sialic acid, which are attached to N- and/or O-linked glycans ().Polysialylation is mainly known to control the developmental plasticity of the vertebrate nervous system by modulating cell-cell and cell.

    Regulation. The fact that PSA can be rapidly expressed at the cell surface, 23, 27, 29 along with the demonstration of relatively fast changes in the morphology and contacts of cells expressing high amounts of PSA-NCAM, 34 raises the possibility that polysialylation may be involved in rapid modulation of cell surface interactions. Rapid conformational changes can affect neurons and glia. Inhibition of polysialylation- of neural cell adhesion molecule in the kelly neuroblastoma cell line by hexane extracts of the roots of Withania somnifera 2 nd Glycobiology World Congress August , Atlanta, USA. Nada Al-Hasawi and Sanaa Amine. Kuwait University, State of Kuwait. Posters & Accepted Abstracts: J Glycobiol. Abstract.

      The formation of appropriate neuronal circuits is an essential part of nervous system development and relies heavily on the outgrowth of axons and dendrites and their guidance to their respective targets. This process is governed by a large array of molecules, including glial cell line-derived neurotrophic factor (GDNF) and the neural cell adhesion molecule (NCAM), the interaction of which. of the Neural Cell Adhesion Molecule NCAM This book contains review articles that produce a snapshot of recent developments in the field of the neural cell adhesion molecule NCAM. The chapters are grouped into sections reflecting various aspects of NCAM structure and function. The themes cover the structural basis of cell adhe-.


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Regulation of neural cell adhesion molecule polysialylation state by Helen Christine Gallagher Download PDF EPUB FB2

The up- and downregulation of polysialic acid–neural cell adhesion molecule (PSA–NCAM) expression on motorneurons during development is associated respectively with target innervation and synaptogenesis, and is regulated at the level of PSA enzymatic biosynthesis involving specific polysialyltransferase by:   T he polysialic acid component of neuronal cell adhesion molcule (NCAM) 1 serves as a temporally regulated modulator of a variety of cell interactions during development (for review see reference 38), with effects having been documented for the facilitation of guidance and targeting of axons (42, 43), migration of neuronal (15, 33), and glial precursors, and development of muscle myotubes ().Cited by: Neural cell adhesion molecule (NCAM) is a surface glycoprotein and is a member of the immunoglobulin superfamily of molecules.

There are three isoforms of NCAM, each of which is expressed differentially during development, undergoing posttranslational modification in phosphorylation and sulfation (Hoffman and Edelman, ). Neural cell adhesion molecule (NCAM, CD56) is a transmembrane glycoprotein modulating cell–cell and cell–matrix interactions.

An additional post-translational modification of NCAM is the α2,8. Regulation of Neural Cell Adhesion Molecule Polysialylation: Evidence for Nontranscriptional Control and Sensitivity to an Intracellular Pool of Calcium.

Kochlamazashvili G, Senkov O, Grebenyuk S, Robinson C, Xiao MF, Stummeyer K, et al. Neural cell adhesion molecule-associated polysialic acid regulates synaptic plasticity and learning by restraining the signaling through GluN2B-containing NMDA receptors. J Neurosci ; – doi: /JNEUROSCI Neural Cell Adhesion Molecule Polysialylation Enhances the Sensitivity of Embryonic Stem Cell‐Derived Neural Precursors to Migration Guidance Cues.

a Story with Many Tales: From Regulation of Cell Cycle Progression/Exit of Neural Stem Cells to Brain Structure and Function, Stem Cells International, //,( Neural Cell Adhesion Molecule Polysialylation Enhances the Sensitivity of Embryonic Stem Cell-Derived Neural Precursors to Migration Guidance Cues TAMARA GLASER,a CLAUDIA BROSE,a ISABELLE FRANCESCHINI,b KATJA HAMANN,a ALINA SMORODCHENKO,c FRAUKE ZIPP,c MONIQUE DUBOIS-DALCQ,b OLIVER BRUSTLE¨ a.

Gallagher HC, Odumeru OA, Regan CM () Regulation of neural cell adhesion molecule polysialylation state by cell-cell contact and protein kinase C delta. J Neurosci Res PubMed Google Scholar.

K.J. Murphy, A.W. O’ Connell, C.M. ReganRepetitive and transient increases in hippocampal neural cell adhesion molecule polysialylation state following multi-trial spatial training Journal of Neurochemistry, 67 (), pp.

Among the large set of cell surface glycan structures, the carbohydrate polymer polysialic acid (polySia) plays an important role in vertebrate brain development and synaptic plasticity. The main carrier of polySia in the nervous system is the neural cell adhesion molecule NCAM.

As polySia with chain lengths of more than 40 sialic acid residues was still observed in brain of newborn Ncam. Regulation of neural cell adhesion molecule polysialylation state by cell-cell contact and protein kinase C delta.

Gallagher HC, Odumeru OA, Regan CM. J Neurosci Res, 61(6), 01 Sep Cited by: 21 articles | PMID: During polysialylation, both STX and PST catalyze the transfer of multiple Sia residues from the activated sugar nucleotide precursor, CMP-Neu5Ac (Sia), to terminal Sia residues on N- and Olinked oligosaccharide chains on acceptor glycoproteins, including the neural cell adhesion molecule (NCAM), which is the major carrier protein of polySia.

Birgit Weinhold's 61 research works with 2, citations and 2, reads, including: Podocyte-Specific Sialylation-Deficient Mice Serve as a Model for Human FSGS. The neural cell adhesion molecule NCAM1 appears on early embryonic cells and is important in the formation of cell collectives and their boundaries at sites of morphogenesis.

()In cell adhesion, CD56 contributes to cell-cell adhesion or cell-matrix adhesion during embryonic development. ()The experimental data clearly show that only the embryonic NCAM molecule.

Enter search terms. Keep search filters New search. Advanced search. In neuronal tissue, an adhesion molecule with a high impact on cellular processes is the neural cell adhesion molecule (NCAM; Rutishauser ). Interestingly, NCAM was also detected during pre- and postnatal development in the testis (Moller et al.

; Orth and Jester ). During the essential neonatal ending of mitotic quiescence of. C Wang, W F Pralong, M F Schulz, G Rougon, J M Aubry, S Pagliusi, A Robert, J Z Kiss; Functional N-methyl-D-aspartate receptors in O-2A glial precursor cells: a critical role in regulating polysialic acid-neural cell adhesion molecule expression and cell migration.

Given that cell proliferation and migration from the niche is observed in liver regeneration, we hypothesized that the antagonistic functions of NCAM and polySia‐NCAM in the regulation of cell adhesion and cell migration (proven for the nervous tissue) may play a significant role during liver development and regeneration.

The gain of migratory properties reflects phenotypically in the expression of several epithelial and mesenchymal markers. 8, 9 Among them, the neural cell adhesion molecule (NCAM) is a surface glycoprotein that, in the nervous system, lung, and gut, regulates morphogenetic processes relative to cell migration and tissue differentiation and, in.

Walsh, F.S., Furness, J., Moore, S.E., Ashton, S., and Doherty, P. (). Use of the neural cell adhesion molecule VASE exon by neurons is associated with a specific down-regulation of neural cell adhesion molecule-dependent neurite outgrowth in the developing cerebellum and hippocampus.

Journal of Neurochemis –  In the hippocampus, morphological synaptic plasticity, supported by regulation of neural cell adhesion molecule (NCAM) polysialylation status, is crucial to information storage. The recent description of polysialylated neurons in the various fields of the medial PFC suggests these structures to possess a similar capacity for synaptic plasticity.Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal gh CD56 is often considered a marker of neural lineage commitment due to its discovery site, CD56 expression is also found in, among others, the hematopoietic system.